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Bernardo Manuel De Sousa Pinto
Luís Filipe Ribeiro de Azevedo
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Suitable for English-speaking students
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[ms_accordion style=”simple” type=”1″ class=”” id=””] [ms_accordion_item title=”Objectives” color=”” background_color=”” close_icon=”” open_icon=”” status=”open”]
The evidence synthesis studies such as systematic reviews and meta-analysis studies have emerged in order to address the massive and growing accumulation of scientific evidence with diferent study designs and quality levels on specific issues. This studies have a double objective: synthethize evidence and analyse and explain of the heterogeneity found. This curricular unit aims to address methodological issues and essential practices among evidence synthesis studies on that area of health research.
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[ms_accordion_item title=”Learning outcomes and competences” color=”” background_color=”” close_icon=”” open_icon=”” status=”open”]
At the end of this curricular unit, students should be able to: adequately define clinical research questions in this context; plan and conduct adequate bibliographic searches; define study selection criteria and assess the quality of included studies; extract and process data from included studies; understand and apply statistical methods in the context of a systematic review and meta-analysis; present, write, and critically appraise systematic reviews and meta-analysis.
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[ms_accordion_item title=”Working method” color=”” background_color=”” close_icon=”” open_icon=”” status=”open”]
Presencial
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[ms_accordion_item title=”Pre-requirements (prior knowledge) and co-requirements (common knowledge)” color=”” background_color=”” close_icon=”” open_icon=”” status=”open”]
Not applicable.
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[ms_accordion style=”simple” type=”1″ class=”” id=””] [ms_accordion_item title=”Program” color=”” background_color=”” close_icon=”” open_icon=”” status=”open”]
Introduction to Scientific Research in Health and Medicine and Evidence Based Medicine.
Evidence synthesis studies – definitions and classification.
Systematic Reviews and Meta-analysis – operational phases:
Research question formulation;
Bibliographic searches;
Studies selection;
Data extraction and processing;
Study quality assessment;
Statistical analysis in evidence synthesis studies – Meta-Analysis;
Assessing between study heterogeneity;
Publication and other bias in evidence synthesis studies;
Presenting a protocol for a systematic review and meta-analysis;
Writing and publishing a systematic review and meta-analysis.
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[ms_accordion_item title=”Teaching methods and learning activities” color=”” background_color=”” close_icon=”” open_icon=”” status=”open”]
After the theoretical presentation of each topic students will perform practical assignments, individual and in group, typically using specific software. An e-learning platform will be used to support theoretical and practical classes.
Evaluation: Theoretical test (70%); Presentation of a work (30%)
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[ms_accordion_item title=”Software” color=”” background_color=”” close_icon=”” open_icon=”” status=”open”]
Software Review Manager (RevMan) [Computer program]. Version 5.4, The Cochrane Collaboration, 2020. Available at https://training.cochrane.org/online-learning/core-software-cochrane-reviews/revman
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[ms_accordion_item title=”Evaluation Type” color=”” background_color=”” close_icon=”” open_icon=”” status=”open”]
Distributed evaluation without final exam
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[ms_accordion_item title=”Eligibility for exams” color=”” background_color=”” close_icon=”” open_icon=”” status=”open”]
Presence in 75% of the classes.
To be approved the student will have to obtain a minimum grade of 9.5 (in a scale 0-20) in the the final grade of the course (70% Final Written Examination + 30% Practical Work).
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[ms_accordion_item title=”Calculation formula of final grade
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Evaluation: Theoretical test (70%); Presentation of a practical work (30%)
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[ms_accordion_item title=”Examinations or Special Assignments” color=”” background_color=”” close_icon=”” open_icon=”” status=”open”]
In this course the students will have to complete a set of practical exercices as part of the practical examination.
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[ms_accordion_item title=”Special assessment (TE, DA, …)” color=”” background_color=”” close_icon=”” open_icon=”” status=”open”]
Special assessment periods will be allowed for typical cases, including employed students and members of the students’ representatives association.
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[ms_accordion_item title=”Mandatory literature” color=”” background_color=”” close_icon=”” open_icon=”” status=”open”]
Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors); Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019). Cochrane, 2019. Available from www.training.cochrane.org/handbook, John Wiley & Sons Ltd., 2019. ISBN: 9781119536659
Sutton, A. J., Abrams, K.R., Jones, D. R., Sheldon, T. A. & Song, F.; Methods for Meta-analysis in Medical Research, John Wiley & Sons, Ltd., 2000
Borenstein, M., Hedges, L.V., Higgins, J.P.T., & Rothstein, H.R. ; Introduction to Meta-Analysis. , : John Wiley & Sons., 2009
Welton, N.J., Sutton, A.J., Cooper, N., Abrams, K.R., & Ades, A.E. ; Evidence Synthesis for Decision Making in Healthcare. , Wiley-Blackwell, 2012
Petitti, D.B. ; ). Meta-Analysis, Decision Analysis, and Cost-Effectiveness Analysis: Methods for Quantitative Synthesis in Medicine (2nd Ed). , New York: Oxford University Press, 2000
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